Bioerodible Polymers
These excipients contain chemical bonds throughout their structure which are susceptible to hydrolysis. Due to the hydrophobic nature of the materials, water is unable to dissolve or enter the bulk polymer matrix, resulting in degradation from the surface only in a layer-by-layer fashion, thus eluting any dispersed pharmaceutical within the excipient polymer in a controlled manner.
Poly(ortho esters)
Poly(ortho esters) type II and IV. These polymers offer great variety in mechanical properties and drug elution profiles independently of each other.
Poly(ortho esters) tend to undergo surface erosion unlike most other polyesters, which undergo bulk degradation.
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