Polymersomes are interesting in that they have a unique combination of advantageous properties compared to liposomes, dendrimers, micelles and solid particles, for use in nanomedicine and controlled release applications. These properties include:

• Large loading capacity of both hydrophobic and hydrophilic agents
• Site-specific targetting possible by polymersome surface derivation
• High formulation and in-vivo stability
• Possible to dial in a range of bioresorbtion rates using FDA approved materials

Chempilots provides tailored polymer synthesis for polymersome use under relevant GLP/GMP guidelines as well as assistance in developing formulations and formulation processing.

Tailored polymers for polymersome formulation
By proper tailoring of the amphiphilic blockcopolymers that make up the shell of polymersomes in aqueous environments, the following parameters can be controlled: Form, size, bioresorbtion rate, stability, shell thickness and permeability, surface derivation anchors.

Site-specific targeting
Polymersome surfaces can by proper choice of polymerization conditions be made with handles that enable derivation of surfaces with a controlled amount of functional groups. Popular examples for such functional groups are:

• Aminogroups (Bioconjugation)
• Aldehydegroups  (Bioconjugation)
• Carbon double bonds (Hydrosilation)
• Carbon triple bonds (Click-reaction)

To achieve site-specific targeting of polymersomes biological recognition motives can be attached to the polymersomes surface by either standard bioconjugation techniques, click-chemistry routes or other coupling methods.

Polymersome formulation
Chempilots can assist with drug/imaging/diagnostic agent loading of polymersomes for initial in-vitro and animal trials, surface derivation as well as in-vitro evaluation of release, degradation and stability profiles.

Contact
Call Christian Elbek on +45 4495 1661 or send us an e-mail for a discussion of how we can potentially assist you with formulation and supply of polymersomes customized to your needs.