Controlled drug release
Chempilots has extensive experience in the development of polymeric systems for transporting and releasing substances under specific conditions. As such, developing polymer systems for controlled drug release is one of our major activities.
Polymeric drug release systems experience
Our experience includes:
- Formulation engineering to develop an injection-molding method for pills containing morphine and other high-potency systemic drugs released by 0-order kinetics. The pills are used in the management of severe pain.
- Processing of silver complexes for use in polymer-based medical devices, hydrocolloid wound dressings and hydrophilic coatings for urology catheters.
- Synthesis of new nitrogen-monooxide-loaded polymers, and formulation of polymeric coating systems to obtain NO-release profiles applicable for less invasive cardio-vascular procedures.
- Design of open-cell polyurethane foam devices impregnated with a polymeric vehicle containing analgetics. The product is indicated for local sustained pain-relief after rectal surgery.
- Development of implantable hydrogels with release profiles of anti-septic and anti-biotic agents.
- Formulation of mousse in pressurized canisters for transdermal delivery of steroids in the treatment of psoriasis and other skin diseases.
Design of controlled drug release systems
Chempilots offers custom design of polymeric delivery systems encompassing the following elements:
- Polymeric systems design to achieve wanted drug release profiles
- Drug dissolution measurement
- Drug solubility and stability issues
- Selection of biocompatible formulation materials
- Physical-chemical compatibility issues of polymer/drug/excipients
Process development
Whenever feasible, delivery-system design and process engineering should be performed concurrently. Our expertise in polymer processing and capabilities within chemical engineering and unit operations include:
- Polymer synthesis, fractionation, dissolution/swelling, mixing, and compounding
- Drug substance and excipients wet and dry operations, e.g. dissolution, mixing, suspension, filtration, and drying
- Foam technology, such as two-component injection molding
- Adhesives
- Coating
- Sterilization
From test samples to pilot production
Based on our lab bench work, we can supply samples for customer visualization and testing purposes.
We also offer engineering scenarios and upscaling studies around new or critical processes. Based on this, Chempilots can install prototype equipment or build a pilot line in our own clean rooms. We can provide product samples produced under a pre-agreed quality system for pre-clinical tests (GLP), etc.
Chempilots can also establish a full operational pilot line (QA) in our clean room area, or support our customers in transferring and implementing a production facility at a site selected by the customer.
Drug handling capabilities
Chempilots is not a pharmaceutical company. A specific handling assessment on the active pharmaceutical ingredient (API) will need to be conducted prior to acceptance of a project. Such assessments will include personnel safety and the concern for ongoing and future activities at our premises. We are approved to handle a variety of chemicals and euphoric substances for R&D purposes. Production of any APIs will require notification to our competent local authority, the Danish Medicines Agency, Lęgemiddelstyrelsen.
Contact us
For further information please contact Richard Schmidt on +45 4495 1661 or by e-mail.
